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Symbol
Name
ID

Msh2
mutS homolog 2
MGI:101816

Phenotype annotations related to digestive/alimentary system

Darker colors indicate more annotations

Human Phenotypes

Gastrointestinal hemorrhage

Neoplasm of the rectum

Colonic diverticula

Adenocarcinoma of the colon

Hereditary nonpolyposis colorectal carcinoma

Adenomatous colonic polyposis

Colon cancer

Intestinal polyposis

Neoplasm of the stomach

Constipation

Nausea and vomiting

Neoplasm of the liver

Hepatocellular carcinoma

Benign gastrointestinal tract tumors

Adenocarcinoma of the small intestine

Duodenal adenocarcinoma

Disease(s) Associated with MSH2

colorectal cancer

Lynch syndrome

Lynch syndrome 1

mismatch repair cancer syndrome

Muir-Torre syndrome

Mouse Phenotypes		colon polyps	increased gastrointestinal tumor incidence	increased intestinal adenocarcinoma incidence	increased small intestine adenocarcinoma incidence	increased intestinal adenoma incidence
Availability	Mouse Genotype	colon polyps	increased gastrointestinal tumor incidence	increased intestinal adenocarcinoma incidence	increased small intestine adenocarcinoma incidence	increased intestinal adenoma incidence
	Msh2^tm1Htr/Msh2^tm1Htr
	Msh2^tm1Rak/Msh2^tm1Rak
	Msh2^tm1Whl/Msh2^tm1Whl
	Msh2^tm2.2Rak/Msh2^tm2.2Rak
	Msh2^tm1Rak/Msh2⁺
	Msh2^tm2.1Rak/Msh2^tm2.1Rak Tg(Vil1-cre)20Syr/0 (conditional)
	Msh2^tm1Rak/Msh2^tm2.1Rak Tg(Vil1-cre)20Syr/0 (conditional)
	Msh2^tm2.1Rak/Msh2^tm3.1Rak Tg(Vil1-cre)20Syr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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